Doesn't it wear you down?
→   피곤하지않아?

[예문]
wear (somebody) down : ~를 피곤하게 하다, 힘들게 하다.

A:How do you like living in the big city?
 대도시에 사는것이 어때?

B: I love it. It's always exciting there's so much to do.
  좋아. 항상 신나,할게 많거든.

A: Doesn't it wear you down?
  피곤하지 않아?

B:No,There's always something to learn and that gives me energy.
  아니, 언제라도 배울게 있고 기운나게 해.